ANXA6抗体

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     Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: Mouse kidney tissue, Primary antibody: P07083(ANXA6 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07083(ANXA6 Antibody) at dilution 1/17. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07083(ANXA6 Antibody) at dilution 1/17. (Original magnification: ×200)    

  
  

ANXA6 (Annexin A6) is a member of the annexin protein family, characterized by calcium-dependent membrane-binding properties and involvement in diverse cellular processes such as membrane organization, signal transduction, and intracellular trafficking. This 67-72 kDa protein contains eight annexin repeats, distinguishing it from other annexins that typically have four. ANXA6 is implicated in regulating cholesterol homeostasis, endocytosis, and exocytosis, with roles in pathologies like cancer, diabetes, and cardiovascular diseases. Its expression varies across tissues, showing high levels in the liver, adrenal glands, and endothelial cells.

ANXA6 antibodies are essential tools for studying the protein’s localization, interactions, and expression patterns. They are widely used in techniques including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Researchers employ these antibodies to explore ANXA6’s dual role in cancer—acting as both a tumor suppressor and promoter depending on context—and its involvement in membrane repair mechanisms or viral entry pathways. Commercially available ANXA6 antibodies are raised in various hosts (e.g., rabbit, mouse) and validated for specificity using knockout cell lines or siRNA knockdown. Proper validation remains critical due to potential cross-reactivity with other annexins. Recent studies also highlight ANXA6 as a biomarker candidate, driving demand for reliable antibodies in diagnostic and therapeutic research.