HOXB13抗体

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     Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane: PC3 cells, Primary antibody: P07349(HOXB13 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

The HOXB13 antibody is a valuable tool in biomedical research, particularly in studying the role of the HOXB13 protein, a member of the homeobox (HOX) transcription factor family. HOX genes are critical in embryonic development, regulating body patterning and tissue differentiation. HOXB13. located on chromosome 17q21. is specifically implicated in posterior development, including the prostate, colon, and rectum. Its expression persists in certain adult tissues, where it regulates cell proliferation, differentiation, and apoptosis.

HOXB13 gained prominence due to its link to hereditary prostate cancer. Germline mutations in HOXB13 (e.g., G84E) are associated with increased prostate cancer risk. The antibody is widely used in immunohistochemistry (IHC) to detect HOXB13 protein expression in tumor tissues, aiding in cancer subtyping and prognosis. For instance, HOXB13 is a sensitive marker for prostatic adenocarcinoma, helping distinguish it from carcinomas of other origins.

Researchers also utilize HOXB13 antibodies to explore its regulatory roles in androgen receptor (AR) signaling and interactions with tumor suppressors like CDKN1B. Commercial HOXB13 antibodies (e.g., clone SP348) are validated for specificity in applications like Western blot, IHC, and immunofluorescence. Challenges include optimizing protocols to address cross-reactivity with other HOX proteins. Overall, HOXB13 antibodies are essential for unraveling developmental biology mechanisms and advancing cancer diagnostics and therapeutics.