WNT10A抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P05547(WNT10A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05547(WNT10A Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of WNT10A Antibody**

WNT10A is a secreted glycoprotein belonging to the Wnt family, which plays critical roles in embryonic development, tissue homeostasis, and stem cell regulation by activating the Wnt/β-catenin signaling pathway. It is particularly essential for the development of ectodermal appendages (e.g., teeth, hair, nails) and skeletal structures. Mutations in the *WNT10A* gene are linked to human disorders such as odonto-onycho-dermal dysplasia (OODD), Schöpf-Schulz-Passarge syndrome, and severe tooth agenesis.

WNT10A antibodies are immunological tools designed to detect and study the expression, localization, and function of the WNT10A protein. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to investigate Wnt signaling dynamics in developmental biology, cancer research (e.g., tumorigenesis, metastasis), and regenerative medicine. Both monoclonal and polyclonal WNT10A antibodies are available, with specificity validated across species (human, mouse, rat).

Research utilizing WNT10A antibodies has advanced understanding of its role in tissue-specific stem cell niches, crosstalk with other signaling pathways (e.g., FGF, BMP), and potential therapeutic targets for genetic or degenerative diseases. However, challenges remain due to the complexity of Wnt ligand-receptor interactions and post-translational modifications influencing antibody binding efficiency.