VAV3抗体

The VAV3 antibody is a research tool used to detect and study the VAV3 protein, a member of the VAV family of guanine nucleotide exchange factors (GEFs). VAV3 plays a critical role in intracellular signaling by activating Rho/Rac GTPases, which regulate diverse cellular processes such as cytoskeletal reorganization, cell proliferation, migration, and differentiation. It contains multiple functional domains, including a Dbl-homology (DH) domain, a pleckstrin-homology (PH) domain, and a cysteine-rich domain (CH), which mediate interactions with signaling molecules. VAV3 is activated by phosphorylation via receptor tyrosine kinases or immune receptors, enabling its GEF activity. Dysregulation of VAV3 has been implicated in cancer, neurological disorders, and cardiovascular diseases. In oncology, VAV3 overexpression or mutations are associated with tumor progression, metastasis, and therapy resistance in cancers like prostate, breast, and glioblastoma. Antibodies targeting VAV3 are essential for techniques such as Western blotting, immunohistochemistry, and immunofluorescence, enabling researchers to investigate its expression, localization, and post-translational modifications. These antibodies also aid in studying VAV3's role in signaling pathways and its potential as a therapeutic target or biomarker. Commercial VAV3 antibodies are typically validated for specificity and sensitivity across human, mouse, or rat samples, with applications spanning basic research and preclinical studies.