TRARG1抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lovo cells, 231 cells, Primary antibody: P05469(TRARG1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05469(TRARG1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05469(TRARG1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The TRARG1 (Trafficking Regulator of GLUT4 (SLC2A4) 1) antibody is a research tool used to study the expression and function of the TRARG1 protein, which plays a critical role in intracellular vesicle trafficking and metabolic regulation. TRARG1. also known as C12orf4. was initially identified as a regulator of GLUT4. the insulin-responsive glucose transporter essential for glucose uptake in adipose and muscle tissues. TRARG1 facilitates GLUT4 vesicle translocation to the plasma membrane in response to insulin signaling, linking it to glucose homeostasis and insulin sensitivity. Dysregulation of TRARG1 has been implicated in metabolic disorders, including type 2 diabetes and obesity.

TRARG1 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable the detection of TRARG1 via techniques such as Western blotting, immunofluorescence, and immunohistochemistry, aiding in the study of its subcellular localization, tissue distribution, and interaction partners. Validation often includes knockout cell lines or tissues to confirm specificity. Commercially available TRARG1 antibodies are widely used in diabetes research, molecular metabolism studies, and investigations into insulin resistance mechanisms. Recent studies also explore TRARG1's potential roles beyond glucose metabolism, such as in cancer cell signaling and neurological processes, highlighting its broader biological significance. Proper antibody selection and validation remain crucial due to occasional cross-reactivity or batch variability.