TRPM3抗体

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05454(TRPM3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of TRPM3 Antibodies**

TRPM3 (Transient Receptor Potential Melastatin 3) is a calcium-permeable ion channel belonging to the TRP superfamily, which plays critical roles in sensory transduction, thermosensation, and cellular calcium homeostasis. TRPM3 is expressed in various tissues, including the nervous system, pancreatic β-cells, and the retina. It is activated by heat, chemical ligands (e.g., pregnenolone sulfate), and mechanical stimuli, contributing to processes like insulin secretion, nociception, and detection of noxious heat.

TRPM3 antibodies are research tools designed to detect and study the expression, localization, and function of TRPM3 channels. These antibodies are crucial for immunohistochemistry, Western blotting, and flow cytometry, enabling investigations into TRPM3's physiological roles and its involvement in diseases. For instance, TRPM3 dysfunction has been linked to neuropathic pain, glaucoma, and metabolic disorders.

Recently, TRPM3 autoantibodies have gained attention in autoimmune and neurological contexts. In rare cases, autoantibodies targeting TRPM3 are associated with encephalitis and neuropathy, suggesting an autoimmune mechanism disrupting channel activity. Research on such antibodies aids in understanding autoimmune pathogenesis and developing diagnostic biomarkers or therapeutic strategies.

Overall, TRPM3 antibodies serve as vital reagents in both basic research and clinical applications, bridging molecular insights with disease mechanisms.