EI24抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05437(EI24 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The EI24 antibody targets the EI24 protein, encoded by the *EI24* (etoposide-induced 24) gene, initially identified as a p53-responsive gene induced during DNA damage or stress. EI24 plays critical roles in apoptosis, autophagy, and tumor suppression. It localizes to the endoplasmic reticulum (ER) and regulates ER stress-induced apoptosis by interacting with pro-survival Bcl-2 family proteins. Studies suggest EI24 promotes autophagy by facilitating autophagosome-lysosome fusion and participates in mitochondrial quality control. Dysregulation of EI24 is linked to cancer progression, with reduced expression observed in breast, colorectal, and other cancers, correlating with poor prognosis.

EI24 antibodies are widely used in research to detect protein expression via Western blotting, immunohistochemistry, and immunofluorescence. These tools help elucidate EI24's functional mechanisms in cellular stress responses, tumorigenesis, and therapeutic resistance. Commercial EI24 antibodies are validated for specificity across human and murine samples, aiding studies on its role as a tumor suppressor and potential biomarker. Recent research also explores EI24's involvement in metabolic disorders and neurodegenerative diseases, highlighting its broader pathophysiological relevance. Ongoing efforts aim to clarify EI24's molecular interactions and therapeutic potential in targeting cancer or autophagy-related conditions.