ZFP36L2抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: P05417(ZFP36L2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05417(ZFP36L2 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

ZFP36L2 (zinc finger protein 36-like 2), also known as Berg36. BRF2. or ERF-2. is a member of the TIS11 family of RNA-binding proteins. It functions as a post-transcriptional regulator by binding to AU-rich elements (AREs) in the 3' untranslated regions (UTRs) of target mRNAs, promoting their degradation or translational repression. This protein plays critical roles in cellular processes such as cell cycle progression, apoptosis, immune response, and inflammation. Dysregulation of ZFP36L2 has been implicated in cancers, autoimmune disorders, and cardiovascular diseases, highlighting its importance in both physiological and pathological contexts.

Antibodies targeting ZFP36L2 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to investigate ZFP36L2’s tissue-specific distribution, subcellular dynamics (e.g., cytoplasmic shuttling), and association with RNA-protein complexes. Validated antibodies typically demonstrate specificity through knockout cell line controls or siRNA-mediated knockdown experiments. Researchers also utilize these antibodies to explore ZFP36L2’s role in stress responses, its interplay with signaling pathways (e.g., MAPK/ERK), and its potential as a biomarker or therapeutic target. Commercial ZFP36L2 antibodies are often raised against conserved epitopes, such as the N-terminal or C-terminal regions, and are available in multiple host species with various conjugates for experimental flexibility.