TBX1抗体

The TBX1 antibody is a crucial tool for studying the TBX1 transcription factor, a member of the T-box gene family involved in embryonic development. TBX1 plays a pivotal role in regulating the formation of structures derived from the pharyngeal arches, including the thymus, parathyroid glands, and cardiac outflow tract. It is encoded by the TBX1 gene located on human chromosome 22q11.2. a region linked to DiGeorge syndrome (22q11.2 deletion syndrome), characterized by congenital heart defects, craniofacial abnormalities, and immune dysfunction. Researchers use TBX1 antibodies to investigate its expression patterns, localization, and function in developmental processes, disease models, and regenerative studies. These antibodies are typically validated via techniques like Western blotting, immunohistochemistry, or immunofluorescence, often using knockout controls to confirm specificity. Commercially available TBX1 antibodies are produced in various hosts (e.g., rabbit, mouse) and formats (monoclonal/polyclonal). Their applications span developmental biology, cardiology, and genetic disorder research, particularly in elucidating mechanisms underlying TBX1 haploinsufficiency or mutations. Proper antibody validation remains essential, as off-target binding can complicate interpretations in complex tissues where TBX1 is expressed transiently or at low levels.