TAF10抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human lung cancer tissue, Primary antibody: P05390(TAF10 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05390(TAF10 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05390(TAF10 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The TAF10 antibody is a crucial tool in studying the role of TATA-box binding protein-associated factor 10 (TAF10), a subunit of the TFIID complex, which is essential for RNA polymerase II-mediated transcription. TAF10. part of the transcription factor IID (TFIID), binds TBP (TATA-box binding protein) and other TAFs to form a multiprotein complex that recognizes core promoters, facilitating the assembly of the preinitiation complex. TAF10 plays a dual role in transcription regulation, contributing to both basal and activated transcription by interacting with activators, chromatin modifiers, and other cofactors. Its involvement in histone acetylation and chromatin remodeling underscores its importance in maintaining transcriptional fidelity and cell viability.

Studies have linked TAF10 to critical biological processes, including cell cycle regulation, differentiation, and development. Dysregulation or mutations in TAF10 are associated with diseases such as cancer and neurodegenerative disorders, highlighting its biomedical relevance. The TAF10 antibody enables researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunoprecipitation, chromatin immunoprecipitation (ChIP), and immunofluorescence. Specificity and sensitivity of the antibody are vital for distinguishing TAF10 from homologous proteins and validating its role in transcriptional mechanisms. By elucidating TAF10's functions, this antibody contributes to understanding gene regulation dynamics and potential therapeutic targets in disease contexts.