STYK1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: P05373(STYK1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

STYK1 (Serine/Threonine/Tyrosine Kinase 1), also known as NOK or MST3. is a member of the protein kinase superfamily, characterized by its dual-specificity kinase activity. Structurally, it contains a conserved kinase domain but lacks extracellular and transmembrane regions, distinguishing it from typical receptor tyrosine kinases. STYK1 is implicated in regulating cellular processes such as proliferation, apoptosis, and migration, primarily through phosphorylation-mediated signaling pathways. Its overexpression has been observed in various cancers, including breast, lung, and liver carcinomas, where it correlates with tumor growth, metastasis, and poor prognosis. However, its exact physiological and pathological mechanisms remain incompletely understood, partly due to the absence of a known specific ligand or upstream regulators.

STYK1 antibodies are essential tools for studying its expression, localization, and function in both normal and diseased tissues. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels and subcellular distribution. Commercially available antibodies target specific epitopes, often within the kinase domain, but validation is crucial due to potential cross-reactivity with homologous kinases. Research using these antibodies has highlighted STYK1's potential as a therapeutic target, though drug development is still in early stages. Challenges include clarifying its signaling network and resolving conflicting findings across studies. Continued investigation of STYK1 and its antibodies may advance cancer diagnostics and kinase-targeted therapies.