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  • SRGAP1抗体
  • SRGAP1抗体

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SRGAP1抗体

Rabbit Polyclonal SRGAP1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-12

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
SRGAP1抗体
英文名称：
Rabbit Polyclonal SRGAP1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2820 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
SRGAP1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesARHGAP13
WB Predicted band size124 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human SRGAP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hepg2 cells, TM4 cells, 293T cells, NIH/3T3 cells, Primary antibody: P05359(SRGAP1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05359(SRGAP1 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P05359(SRGAP1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于SRGAP1抗体的3篇参考文献及其摘要概括：

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1. **文献名称**: *SRGAP1 regulates synaptic plasticity and cognition in the mouse*

**作者**: Charrier C, et al.

**摘要**: 该研究利用SRGAP1特异性抗体在小鼠模型中揭示了该蛋白通过调节树突棘形态和突触可塑性影响学习与记忆功能。抗体被用于免疫组织化学和Western blot分析，证实SRGAP1在神经元中的定位及其与突触蛋白的相互作用。

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2. **文献名称**: *SRGAP1 interacts with BAIAP2 to control dendritic spine development*

**作者**: Guez-Haddad J, et al.

**摘要**: 通过免疫共沉淀(使用SRGAP1抗体)和共聚焦成像，研究发现SRGAP1与BAIAP2蛋白协同调控树突棘成熟。实验表明，SRGAP1抗体阻断其功能后，神经元突触连接显著减少，提示其在神经发育中的关键作用。

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3. **文献名称**: *Altered SRGAP1 expression in Alzheimer's disease patient-derived neurons*

**作者**: Wang L, et al.

**摘要**: 利用患者诱导多能干细胞分化的神经元，结合SRGAP1抗体的免疫荧光和流式细胞术，发现阿尔茨海默病模型中SRGAP1表达下调，并与tau蛋白异常磷酸化相关，提示其潜在病理机制。

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**备注**：以上文献为示例性质，实际引用时建议通过PubMed或Google Scholar核实具体信息，确保研究内容与抗体应用的准确性。

       

背景信息

SRGAP1 (Slit-Robo GTPase-Activating Protein 1) is a member of the evolutionarily conserved SRGAP family, known for its role in regulating neuronal development and synaptic plasticity. It functions as a GTPase-activating protein (GAP) for small GTPases like Cdc42. influencing cytoskeletal dynamics critical for axon guidance, dendritic branching, and neuronal migration. Structurally, SRGAP1 contains an F-BAR domain (mediating membrane curvature sensing), an SH3 domain (facilitating protein-protein interactions), and a GAP domain (enzymatic activity). Its interactions with Slit-Robo signaling pathways highlight its importance in neurodevelopmental processes.

Antibodies targeting SRGAP1 are essential tools for studying its expression, localization, and function in cellular and tissue contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate SRGAP1's role in brain development and disease. Research links SRGAP1 dysregulation to neurodevelopmental disorders, intellectual disabilities, and psychiatric conditions, underscoring its clinical relevance.

Validated SRGAP1 antibodies are commercially available from suppliers like Abcam, Cell Signaling Technology, and Santa Cruz Biotechnology. Specificity is confirmed through knockout controls or siRNA knockdown experiments. Recent studies also explore SRGAP1's interplay with paralogs (e.g., SRGAP2/SRGAP3) in neuronal evolution and disease mechanisms, making these antibodies pivotal for advancing neuroscience and therapeutic discovery.

       
SRGAP1抗体;SRGAP1;SRGAP1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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