SIK1抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05340(SIK1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05340(SIK1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The Salt-Inducible Kinase 1 (SIK1) antibody is a crucial tool for studying the SIK1 protein, a serine/threonine kinase belonging to the AMP-activated protein kinase (AMPK) family. SIK1 plays a central role in cellular energy homeostasis, hormone signaling, and circadian rhythm regulation. It is activated by the LKB1 kinase and participates in pathways controlling gluconeogenesis, lipid metabolism, and inflammation by phosphorylating downstream targets like CREB-regulated transcription coactivators (CRTCs) and class IIa histone deacetylases (HDACs). Dysregulation of SIK1 is linked to metabolic disorders, cancer progression, and neurodegenerative diseases.

SIK1 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to detect SIK1 expression, localization, and post-translational modifications (e.g., phosphorylation at Ser577). These antibodies help investigate SIK1's role in signal transduction, drug responses (e.g., glucocorticoids), and disease mechanisms. High-quality SIK1 antibodies are validated for specificity using knockout cell lines or tissues. Some antibodies target specific isoforms or phosphorylated forms, enabling precise study of SIK1 activation states. Researchers rely on these reagents to explore therapeutic strategies targeting SIK1-related pathways in metabolic syndromes, cancer, and inflammation.