SMC4抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 cells, K562 cells, Primary antibody: P05335(SMC4 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 4 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05335(SMC4 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05335(SMC4 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The SMC4 antibody targets the Structural Maintenance of Chromosomes 4 (SMC4) protein, a key component of the condensin complex essential for chromosome organization and stability during cell division. SMC4 belongs to the SMC protein family, which includes ATPases involved in DNA repair, recombination, and chromosome condensation. The condensin complex, comprising SMC4. SMC2. and non-SMC subunits, ensures proper chromatin compaction and sister chromatid resolution during mitosis and meiosis. Dysregulation of SMC4 is linked to genomic instability, a hallmark of cancer and developmental disorders.

Antibodies against SMC4 are widely used in research to study chromosome dynamics, cell cycle regulation, and mitotic errors. They enable detection of SMC4 expression levels, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies utilizing SMC4 antibodies have revealed its overexpression in certain cancers, correlating with poor prognosis, and its role in maintaining mitotic fidelity. These tools also aid in exploring condensin's involvement in 3D genome organization and transcriptional regulation. Validated SMC4 antibodies are critical for elucidating mechanisms underlying chromosomal abnormalities and potential therapeutic targets.