SLC5A6抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05318(SLC5A6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The solute carrier family 5 member 6 (SLC5A6), also known as the sodium-dependent multivitamin transporter (SMVT), is a transmembrane protein responsible for the cellular uptake of pantothenate (vitamin B5), biotin (vitamin B7), and lipoate, as well as the thyroid hormone precursor iodothyronine. It plays a critical role in maintaining cellular homeostasis by mediating sodium-dependent transport of these essential micronutrients across cell membranes. SLC5A6 is widely expressed in tissues, including the intestines, liver, kidneys, and brain, highlighting its importance in nutrient absorption and metabolic regulation.

Antibodies targeting SLC5A6 are valuable tools for studying its expression, localization, and function in both physiological and pathological contexts. They are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate tissue-specific distribution or alterations in diseases like inflammatory bowel disease, neurodegenerative disorders, and cancer. Some studies suggest SLC5A6 dysregulation may contribute to micronutrient deficiencies or metabolic disruptions. Researchers also utilize these antibodies to explore SLC5A6's interaction with pharmaceutical agents, as the transporter influences drug bioavailability. Validation of SLC5A6 antibodies typically involves knockout cell lines or tissues to confirm specificity, given potential cross-reactivity with other solute carriers. Ongoing research aims to clarify its role in disease mechanisms and therapeutic targeting.