SLC25A20抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human thigh malignant fibrous histiocytoma tissue, Primary antibody: P05298(SLC25A20 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P05298(SLC25A20 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05298(SLC25A20 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

SLC25A20. also known as carnitine-acylcarnitine translocase (CACT), is a mitochondrial membrane protein belonging to the solute carrier family 25 (SLC25). It plays a critical role in fatty acid β-oxidation by facilitating the transport of acylcarnitines across the inner mitochondrial membrane, enabling their entry into the mitochondrial matrix for energy production. SLC25A20 deficiency is linked to rare autosomal recessive metabolic disorders characterized by impaired fatty acid oxidation, leading to life-threatening symptoms such as hypoglycemia, cardiomyopathy, and muscle weakness.

Antibodies targeting SLC25A20 are essential tools for studying its expression, localization, and function in cellular and disease contexts. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein levels in tissues or cell lines. Researchers employ SLC25A20 antibodies to investigate metabolic pathways, diagnose genetic disorders, or explore therapeutic strategies for conditions involving fatty acid metabolism defects. Specific validation of these antibodies—through knockout controls or siRNA silencing—is crucial to ensure specificity, given the structural similarities among mitochondrial carrier family proteins. Commercial SLC25A20 antibodies are typically raised against peptide sequences unique to the protein, often within its cytoplasmic or transmembrane domains. Understanding SLC25A20's role and its antibody applications advances research into mitochondrial biology and metabolic diseases.