SLC24A5抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05296(SLC24A5 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The SLC24A5 gene encodes a protein belonging to the solute carrier family 24 (sodium/potassium/calcium exchanger), specifically known as NCKX5. This protein plays a critical role in melanogenesis by regulating calcium homeostasis in melanosomes, influencing the synthesis and distribution of melanin, the pigment responsible for skin, hair, and eye color. A nonsynonymous mutation (rs1426654) in SLC24A5 is strongly associated with reduced melanin production and lighter skin pigmentation, a trait prevalent in European populations. This genetic variant has become a key focus in evolutionary studies exploring the adaptation of human skin color to varying ultraviolet radiation levels.

Antibodies targeting the SLC24A5 protein are widely used in research to investigate its expression, localization, and functional interactions in melanocytes and keratinocytes. These antibodies enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence, aiding in the study of pigmentation disorders, melanoma biology, and the role of SLC24A5 in cellular calcium signaling. Additionally, they contribute to understanding the gene’s involvement in broader physiological processes, including potential links to vitamin D metabolism and skin cancer susceptibility.

As a model antigen, SLC24A5 also serves as a tool to explore population genetics and the evolutionary divergence of pigmentation traits. Its antibodies are pivotal in bridging molecular biology with anthropological studies, offering insights into how genetic diversity shapes human phenotypic variation.