SLC14A1抗体

The SLC14A1 (solute carrier family 14 member 1) gene encodes urea transporter B (UT-B), a transmembrane protein critical for urea transport across cell membranes, primarily in the kidneys and erythrocytes. It facilitates urine concentration by recycling urea in the renal medulla, maintaining osmotic gradients essential for water reabsorption. SLC14A1 antibodies are immunological tools designed to detect and study UT-B expression, localization, and function in physiological and pathological contexts. These antibodies are widely used in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to investigate UT-B's role in renal physiology, including disorders like diabetes insipidus or chronic kidney disease. Additionally, studies explore UT-B's involvement in non-renal tissues, such as its expression in endothelial cells or tumors, where altered urea transport may influence cell survival or tumor microenvironments. Commercially available SLC14A1 antibodies are typically raised in rabbits or mice, targeting specific epitopes of human or murine UT-B isoforms. Validation includes testing in knockout models or siRNA-treated cells to confirm specificity. Research utilizing these antibodies contributes to understanding urea metabolism disorders, potential therapeutic targets, and biomarker discovery for diseases linked to UT-B dysfunction.