SRP68抗体

+ +

•  

   

     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T cells, HepG2 cells, K562 cells, Primary antibody: P05286(SRP68 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

The SRP68 antibody is a research tool designed to detect and study the Signal Recognition Particle 68 kDa (SRP68) protein, a critical component of the eukaryotic signal recognition particle (SRP). The SRP is a ribonucleoprotein complex essential for co-translational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP68. along with SRP72. forms a heterodimer that binds to SRP RNA, stabilizing the complex and facilitating its interaction with ribosomes and signal sequences on nascent polypeptides.

Antibodies against SRP68 are widely used in molecular and cellular biology to investigate SRP assembly, protein translocation mechanisms, and SRP-related pathologies. They enable techniques like Western blotting, immunofluorescence, and immunoprecipitation to analyze SRP68 expression, localization, and interactions. Dysregulation of SRP68 has been implicated in rare genetic disorders, such as congenital neutropenia, where mutations disrupt SRP function, leading to impaired protein synthesis and hematopoietic defects.

These antibodies are also valuable in studying cellular stress responses, as ER-targeting defects can trigger unfolded protein responses. Researchers utilize SRP68 antibodies across model organisms, including humans, mice, and rats, to explore conserved roles in gene expression regulation and disease mechanisms. Commercial variants are typically validated for specificity, often through knockout cell lines, ensuring reliability in experimental applications.