SAMD9L抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: HUVEC cell lysate, Primary antibody: P05247(SAMD9L Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05247(SAMD9L Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P05247(SAMD9L Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The SAMD9L (Sterile Alpha Motif Domain-containing protein 9-like) gene encodes a protein involved in regulating innate immune responses, particularly interferon (IFN)-mediated pathways. It is expressed in various tissues, including immune cells, and plays roles in cell proliferation, apoptosis, and antiviral defense. SAMD9L is localized to endosomal/lysosomal membranes and acts as a scaffold protein, modulating signaling cascades. Notably, gain-of-function mutations in SAMD9L are linked to severe genetic disorders, such as infantile-onset cerebellar ataxia with sensory neuropathy (SCAAN) and familial myelodysplastic syndrome (MDS), often due to dysregulated protein activity that disrupts cellular homeostasis.

SAMD9L antibodies are critical tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding research into its role in immune regulation and disease mechanisms. Commercial SAMD9L antibodies are typically raised against specific epitopes (e.g., N-terminal or C-terminal regions) and validated for specificity across human and model organisms. Recent studies highlight its potential as a therapeutic target, particularly in disorders driven by hyperactive SAMD9L variants. However, challenges remain in standardizing antibody validation and interpreting its complex interactions within signaling networks. Overall, SAMD9L antibodies are indispensable for advancing insights into its dual roles in immunity and pathology.