TRIM34抗体

The TRIM34 antibody is a research tool used to study the Tripartite Motif 34 (TRIM34) protein, a member of the TRIM family of proteins characterized by conserved RING, B-box, and coiled-coil domains. TRIM34. also known as HAP33 or RNF21. is part of the type I TRIM subgroup and shares structural homology with other antiviral TRIM proteins like TRIM5α and TRIM22. It is implicated in innate immunity, particularly in interferon-mediated antiviral responses, and may act as an E3 ubiquitin ligase, modulating immune signaling pathways through protein ubiquitination. Studies suggest TRIM34 contributes to host defense against viral infections, including HIV-1. by interacting with viral capsids or regulating immune sensors. Its expression is induced by interferons and viral stimuli, highlighting its role in adaptive immune regulation. TRIM34 antibodies are utilized in Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression patterns, subcellular localization, and interactions in various cell types, including immune cells and cancer models. Research also explores its potential involvement in autoimmune diseases, cancer progression, and reproductive biology, given its expression in testes and germ cells. However, challenges remain in distinguishing its functions from closely related TRIM family members due to structural similarities and overlapping roles. These antibodies are critical for elucidating TRIM34's mechanisms in health and disease.