RNF148抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10719(FGF1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10719(FGF1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The RNF148 antibody is a research tool designed to target the RING finger protein 148 (RNF148), a member of the RING finger family characterized by a conserved zinc-binding domain critical for E3 ubiquitin ligase activity. RNF148 is implicated in ubiquitination, a post-translational modification process regulating protein degradation, localization, and interactions. While its biological functions remain less characterized compared to other RING family proteins, studies suggest RNF148 may play roles in cellular processes such as cell cycle regulation, DNA repair, or apoptosis, potentially interacting with substrates involved in these pathways. Dysregulation of ubiquitination enzymes like RNF148 is often linked to cancer, neurodegenerative disorders, or immune diseases, making it a subject of interest in disease mechanism research.

RNF148 antibodies are typically developed using recombinant protein fragments or synthetic peptides to ensure specificity. They enable detection and analysis of RNF148 expression levels, subcellular localization (e.g., nucleus, cytoplasm), and interaction partners via techniques like Western blotting, immunofluorescence, or immunoprecipitation. Validated antibodies help explore RNF148's tissue distribution, overexpression/knockdown effects, and its role in ubiquitin-proteasome pathways. However, limited commercial availability and functional data necessitate careful validation for cross-reactivity and batch consistency. Ongoing research aims to clarify RNF148's physiological and pathological relevance, positioning this antibody as a key reagent for dissecting its contributions to cellular homeostasis and disease.