RNF122抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: P05228(RNF122 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

RNF122 (Ring Finger Protein 122) is a member of the RING finger protein family, characterized by a conserved RING domain that confers E3 ubiquitin ligase activity. This enzyme plays a role in the ubiquitin-proteasome system, regulating protein degradation and post-translational modifications. RNF122 is implicated in diverse cellular processes, including cell proliferation, apoptosis, and neural development. Studies suggest its involvement in central nervous system function, with potential links to neurodegenerative diseases and cancer.

Antibodies targeting RNF122 are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study RNF122’s role in physiological and pathological contexts. For example, research has utilized these antibodies to explore RNF122’s regulatory effects on substrates such as the tumor suppressor p53 or its interaction with endoplasmic reticulum-associated degradation pathways.

Despite its emerging significance, RNF122’s full mechanistic landscape remains understudied. Reliable antibodies are critical for validating its tissue-specific expression patterns, particularly in the brain, and for deciphering its dual roles in neurodevelopment and oncogenesis. Ongoing research aims to clarify its therapeutic potential as a biomarker or drug target in diseases like glioblastoma or Alzheimer’s.