KCNJ15抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05227(KCNJ15 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P05227(KCNJ15 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The KCNJ15 antibody is a tool used to detect the KCNJ15 protein, encoded by the *KCNJ15* gene (potassium inwardly rectifying channel subfamily J member 15). This gene is located on chromosome 21 in humans and is part of the inward-rectifier potassium channel family, which regulates cellular electrical activity and potassium ion homeostasis. The KCNJ15 protein, also known as Kir4.2. forms tetramers with two transmembrane domains and plays roles in maintaining resting membrane potential and potassium buffering in various tissues, including the kidneys, pancreas, and brain.

KCNJ15 has been implicated in physiological and pathological processes, such as insulin secretion, neuronal excitability, and renal function. Dysregulation of KCNJ15 is linked to diseases like diabetes, neurodegenerative disorders, and certain cancers. For example, reduced expression is observed in some cancers, suggesting a tumor-suppressive role.

The KCNJ15 antibody is essential for studying its expression patterns, subcellular localization, and interactions in research models. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers also employ it to explore KCNJ15's role in cellular pathways, such as cell proliferation, apoptosis, and ion transport. Both polyclonal and monoclonal variants are available, with specificity validated through knockout controls or peptide blocking assays. Understanding KCNJ15's function via antibody-based studies may advance therapeutic strategies for related diseases.