PUS10抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: A549 cell, Human placenta tissue, A172 cell, NIH/3T3 cell, Jurkat cell, Hela cell lysates, Primary antibody: P13304(EIF2S1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13304(EIF2S1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13304(EIF2S1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The PUS10 antibody is a tool used to study the pseudouridine synthase 10 (PUS10) protein, an enzyme belonging to the pseudouridine synthase family. Pseudouridylation, a common RNA modification, involves isomerizing uridine to pseudouridine (Ψ) in RNA molecules, influencing RNA stability, structure, and function. PUS10 is evolutionarily conserved and plays roles in diverse cellular processes, including ribosomal RNA (rRNA) and transfer RNA (tRNA) modification, apoptosis, and stress responses. It has been implicated in diseases such as cancer, neurodevelopmental disorders, and mitochondrial dysfunction.

Research shows PUS10 interacts with specific RNA targets and may regulate translation or RNA processing. Its dysregulation is linked to hepatocellular carcinoma progression and glioma pathogenesis. Antibodies against PUS10 enable detection of its expression, localization, and interaction partners in techniques like Western blotting, immunofluorescence, or immunoprecipitation. These tools help unravel PUS10's molecular mechanisms, including its role in RNA-mediated pathways or disease contexts.

Current studies focus on characterizing PUS10's catalytic domains, substrate specificity, and tissue-specific functions. Both polyclonal and monoclonal PUS10 antibodies are available, with validation in model organisms like mice and humans. Understanding PUS10's biology via these antibodies may contribute to therapeutic strategies targeting RNA modification pathways.