CENPV抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Raji cell, Hela cell, Jurkat cell, 293T cell, Mouse brain tissue lysate, Primary antibody: P05190(CENPV Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P05190(CENPV Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05190(CENPV Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

CENPV (Centromere Protein V) is a key component of the centromere, a specialized chromosomal region essential for proper chromosome segregation during cell division. It localizes to the inner kinetochore plate and interacts with other centromeric proteins, such as CENP-A and CENP-C, to maintain centromere integrity and ensure accurate microtubule attachment. CENPV plays a role in stabilizing nucleosome structure and regulating mitotic progression, making it critical for genomic stability. Dysregulation of CENPV has been implicated in chromosomal instability disorders and cancer progression.

CENPV antibodies are widely used in research to study centromere architecture, kinetochore assembly, and cell cycle regulation. These antibodies enable the detection and localization of CENPV via techniques like immunofluorescence, western blotting, and chromatin immunoprecipitation (ChIP). They are particularly valuable in investigating diseases linked to centromere dysfunction, including certain cancers and autoimmune conditions (e.g., CREST syndrome), where abnormal centromere protein expression may serve as a diagnostic marker. Commercially available CENPV antibodies are typically raised against specific epitopes of human CENPV, with cross-reactivity tested in common model organisms. Validation includes verification of signal specificity through siRNA knockdown or knockout cell lines. Ongoing studies continue to explore CENPV's role in aging, meiosis, and targeted cancer therapies.