PNPT1抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Jurkat cells, Hela cells, A431 cells, mouse liver tissue tissue, 293T cells, Primary antibody: P05179(PNPT1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P05179(PNPT1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P05179(PNPT1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The PNPT1 (Polyribonucleotide Nucleotidyltransferase 1) antibody is a tool used to detect and study the PNPT1 protein, a critical player in mitochondrial RNA metabolism and innate immune signaling. PNPT1. also known as mitochondrial RNA-processing protein 1. is encoded by the PNPT1 gene and localizes primarily to the mitochondrial matrix. It facilitates RNA import into mitochondria and processes RNA transcripts through its 3'-to-5' exoribonuclease activity. Mutations in PNPT1 are linked to mitochondrial disorders, neurodegenerative diseases, and hearing loss.

The PNPT1 antibody is widely utilized in research to investigate the protein's expression, localization, and function in cellular models and tissues. It aids in understanding PNPT1's role in mitochondrial dysfunction, viral RNA sensing, and its interaction with the RIG-I-like receptor pathway during antiviral responses. Available as monoclonal or polyclonal variants, the antibody is commonly validated for techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers rely on it to explore disease mechanisms, particularly those involving mitochondrial RNA dysregulation and immune signaling defects. Proper validation ensures specificity, crucial for distinguishing PNPT1 from homologous proteins.