PDCD6IP抗体

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P05147(PDCD6IP Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of PDCD6IP Antibody**

PDCD6IP (Programmed Cell Death 6 Interacting Protein), also known as ALIX, is a multifunctional adaptor protein involved in apoptosis, endocytosis, and extracellular vesicle biogenesis. It plays a critical role in the endosomal sorting complex required for transport (ESCRT) pathway, mediating membrane remodeling events such as cytokinesis, viral budding, and exosome formation. ALIX interacts with components of the ESCRT machinery (e.g., TSG101. CHMP4) and apoptotic proteins like PDCD6 (ALG-2), linking cellular processes like programmed cell death and membrane dynamics.

PDCD6IP antibodies are essential tools for studying its diverse functions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect ALIX expression, localization, and protein interactions. These antibodies help elucidate its role in diseases, including cancer (e.g., regulating tumor suppression or metastasis), neurodegenerative disorders (e.g., modulating exosome-mediated pathogenic protein spread), and viral infections (e.g., HIV-1 budding). Researchers also utilize PDCD6IP antibodies to explore its structural domains, such as the Bro1 domain (binding ESCRT-III) and the V domain (interacting with viral proteins), providing insights into therapeutic targeting of ALIX-associated pathways.