P2RX3抗体

The P2RX3 antibody is a research tool targeting the P2X purinoceptor 3 (P2RX3), a ligand-gated ion channel activated by extracellular ATP. P2RX3 is predominantly expressed in sensory neurons, particularly nociceptors, and plays a critical role in pain signaling, mechanosensation, and inflammatory responses. It is implicated in chronic pain conditions, bladder dysfunction, and gastrointestinal disorders. P2RX3 antibodies are widely used to study receptor localization, expression levels, and functional roles in physiological and pathological contexts. These antibodies enable techniques like immunohistochemistry, Western blotting, and flow cytometry, aiding in the validation of P2RX3 as a therapeutic target. Recent studies highlight its involvement in neuropathic pain and visceral hypersensitivity, driving interest in developing P2RX3 antagonists. However, challenges remain in achieving subtype specificity due to structural similarities among P2X receptors. Research utilizing P2RX3 antibodies contributes to understanding ATP-mediated signaling pathways and exploring potential therapies for pain management, overactive bladder, and irritable bowel syndrome. Commercial P2RX3 antibodies are typically validated across species, including human, mouse, and rat models, ensuring broad applicability in preclinical studies.