NPTX1抗体

The Neuronal Pentraxin 1 (NPTX1) antibody is a tool used to detect NPTX1. a protein belonging to the pentraxin family, which is characterized by its pentameric structure and calcium-dependent ligand-binding properties. NPTX1 is predominantly expressed in the central nervous system, where it plays a role in synaptic plasticity, neuronal connectivity, and the remodeling of excitatory synapses. It interacts with AMPA receptors, facilitating their clustering and influencing synaptic strength, which is critical for learning and memory processes. The NPTX1 antibody is widely utilized in neuroscience research to investigate protein localization, expression patterns, and functional roles in both physiological and pathological contexts. It is commonly applied in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize NPTX1 distribution in brain tissues or cultured neurons. Studies involving NPTX1 antibodies have contributed to understanding its implications in neurodegenerative diseases (e.g., Alzheimer’s disease) and neuropsychiatric disorders, where synaptic dysfunction is a hallmark. Commercial NPTX1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes to ensure specificity. Validation steps, including knockout controls, are essential to confirm antibody reliability. Ongoing research continues to explore NPTX1's interactions with other pentraxins (e.g., NPTX2. NPR) and its broader impact on neural network stability.