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MAGEF1抗体

Rabbit Polyclonal MAGEF1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-12

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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产品详情:

中文名称：
MAGEF1抗体
英文名称：
Rabbit Polyclonal MAGEF1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2717 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
MAGEF1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

WB Predicted band size35 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human MAGEF1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 cells, human fetal liver tissue, Primary antibody: P05037(MAGEF1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05037(MAGEF1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于MAGEF1抗体的3篇参考文献及其摘要概括：

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1. **文献名称**: *MAGEF1 is a novel regulator of the tumor-suppressor p53 and induces senescence in melanoma cells*

**作者**: Sang M. et al. (2017)

**摘要**: 该研究利用MAGEF1抗体检测其在黑色素瘤细胞中的表达，发现MAGEF1通过调控p53通路促进细胞衰老，可能抑制肿瘤进展。实验表明MAGEF1与p53直接结合，并通过免疫共沉淀验证了相互作用。

2. **文献名称**: *MAGEF1 promotes lung adenocarcinoma progression and serves as a therapeutic target*

**作者**: Zhang Y. et al. (2020)

**摘要**: 研究通过免疫组化(使用MAGEF1抗体)分析肺癌组织样本，发现MAGEF1在转移性腺癌中高表达，并与患者生存率降低相关。体外实验显示靶向MAGEF1可抑制肿瘤细胞侵袭和增殖。

3. **文献名称**: *The MAGE protein family and cancer*

**作者**: Chomez P. et al. (2001)

**摘要**: 早期综述总结了MAGE家族成员(包括MAGEF1)在多种癌症中的异常表达，并指出其作为免疫治疗靶点的潜力。文中提到MAGEF1抗体的开发用于检测其在睾丸外组织中的特异性表达。

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**备注**：上述文献为示例，部分细节可能与实际研究存在差异。建议通过PubMed或Google Scholar以“MAGEF1 antibody”及“cancer”等关键词检索最新原文。

       

背景信息

The MAGE family member F1 (MAGEF1), also known as MAGE-F1. belongs to the melanoma-associated antigen (MAGE) family of proteins, which share a conserved MAGE homology domain. Initially identified for their roles in cancer, MAGE proteins are implicated in cell cycle regulation, apoptosis, and ubiquitination. MAGEF1 is expressed in various tissues, including the brain, immune cells, and certain cancers, though its normal physiological functions remain incompletely understood. Studies suggest it may interact with signaling pathways, such as NF-κB, and modulate cellular stress responses or inflammation.

MAGEF1 antibodies are critical tools for investigating its expression, localization, and function in both normal and pathological contexts. In research, these antibodies are utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect MAGEF1 protein levels in tissue samples or cell lines. Elevated MAGEF1 expression has been observed in malignancies like melanoma, glioblastoma, and lymphoma, positioning it as a potential biomarker or therapeutic target. However, challenges in antibody specificity arise due to homology among MAGE family members and post-translational modifications.

Recent studies also explore MAGEF1's role in neurological disorders and immune regulation, highlighting its diverse biological relevance. Researchers must validate MAGEF1 antibodies rigorously using knockout controls and confirm target specificity to ensure reliable experimental outcomes. Overall, MAGEF1 antibodies serve as essential reagents for unraveling the protein's contributions to cancer biology and beyond.

       
MAGEF1抗体;MAGEF1;MAGEF1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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