MAGEE1抗体 新品

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P05035(MAGEE1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05035(MAGEE1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P05035(MAGEE1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

MAGEE1 (Melanoma Antigen Family E1) is a member of the MAGE protein family, which shares a conserved MAGE homology domain. Initially identified in melanoma, MAGE genes are classified as cancer-testis antigens due to their restricted expression in normal tissues (primarily testes and placenta) and frequent reactivation in various cancers. MAGEE1. located on the X chromosome, has garnered attention for its potential role in tumorigenesis and immune evasion. Studies suggest it may participate in epigenetic regulation by interacting with chromatin-modifying complexes, influencing gene silencing pathways such as those involving H3K9me3 histone marks. Its overexpression in malignancies like glioblastoma, lung cancer, and hepatocellular carcinoma correlates with poor prognosis, implicating it in promoting cell proliferation, apoptosis resistance, and metastasis.

MAGEE1 antibodies are critical tools for investigating its biological functions and clinical relevance. These antibodies enable detection of MAGEE1 protein expression in tissues or cell lines via techniques like immunohistochemistry, Western blotting, or immunofluorescence. Researchers utilize them to explore MAGEE1's diagnostic or prognostic value, its interaction networks, and its potential as a therapeutic target, particularly in immunotherapy. However, antibody specificity remains a consideration due to homology among MAGE family members. Validated MAGEE1 antibodies contribute to advancing understanding of its oncogenic mechanisms and its role in immune response modulation, supporting efforts to develop targeted cancer therapies or biomarkers.