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  • LOXL2抗体

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LOXL2抗体

Rabbit Polyclonal LOXL2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-12

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
LOXL2抗体
英文名称：
Rabbit Polyclonal LOXL2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2713 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
LOXL2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCMT2DD; HOMGSMR2
Entrez GeneID476
clone3C1F3
WB Predicted band size112.8kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ATP1A1 (AA: 153-288) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using ATP1A1 mouse mAb against Hela (1), HepG2 (2), and A431 (3) cell lysate.    


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       Immunofluorescence analysis of Hela cells using ATP1A1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using ATP1A1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using ATP1A1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using ATP1A1 mouse mAb with DAB staining.    


           

参考文献

以下是关于LOXL2抗体的3篇代表性文献，按研究领域分类简要总结：

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1. **文献名称**: *"Lysyl oxidase-like 2 (LOXL2) is critical for tumor microenvironment and metastasis in breast cancer"*

**作者**: Sánchez-Ortega M, et al.

**摘要**: 该研究通过LOXL2特异性抗体(如ABT-100)在乳腺癌模型中发现，抑制LOXL2可显著减少肿瘤相关纤维化和转移，揭示了LOXL2通过调节细胞外基质重塑促进肿瘤微环境形成的机制。

2. **文献名称**: *"A novel monoclonal antibody targeting LOXL2 inhibits cardiac fibrosis in mice"*

**作者**: Li Y, et al.

**摘要**: 作者开发了一种靶向LOXL2的单克隆抗体(mAb210)，并在小鼠心肌纤维化模型中验证其疗效，结果显示该抗体通过阻断LOXL2的酶活性减轻胶原沉积和心脏功能损伤。

3. **文献名称**: *"LOXL2 in epithelial-mesenchymal transition (EMT): Diagnostic and therapeutic implications in hepatocellular carcinoma"*

**作者**: Peng C, et al.

**摘要**: 研究利用LOXL2抗体(如克隆号EPR20047)检测肝癌组织中LOXL2表达，发现其与EMT标志物(如E-cadherin丢失)相关，并提示LOXL2抗体可能作为肝癌预后标志物或治疗靶点。

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这些文献覆盖了LOXL2抗体在**肿瘤转移**、**纤维化疾病**和**癌症诊断**中的关键作用，可作为研究参考。如需具体实验细节或更近期文献，建议通过PubMed或SciHub进一步检索。

       

背景信息

Lysyl oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family, enzymes critical for modifying the extracellular matrix (ECM) by catalyzing cross-linking of collagen and elastin. LOXL2 is involved in ECM remodeling, cell adhesion, and tissue homeostasis, with emerging roles in fibrosis, cancer metastasis, and angiogenesis. Its dysregulation has been linked to pathological conditions, including liver and lung fibrosis, as well as tumor progression in cancers like breast, colorectal, and squamous cell carcinomas.

LOXL2 antibodies are tools used to detect and study the expression, localization, and function of LOXL2 in research and diagnostic contexts. They are essential for immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF) to assess LOXL2 levels in tissues or cell lines, often correlating its overexpression with disease severity or metastatic potential. Therapeutic LOXL2-targeting antibodies (e.g., AB0023. PXS-5332) are under investigation to inhibit enzymatic activity or disrupt LOXL2-mediated ECM stiffening, aiming to block cancer progression or fibrotic processes.

Challenges in antibody development include ensuring specificity due to structural homology among LOXL family members and addressing post-translational modifications that may affect LOXL2 detection. Validated LOXL2 antibodies are crucial for understanding its dual roles in tissue repair and disease, highlighting its potential as a biomarker or therapeutic target in fibrosis and oncology.

       


LOXL2抗体;LOXL2;LOXL2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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