LLGL1抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05019(LLGL1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P05019(LLGL1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The LLGL1 (Lethal giant larvae homolog 1) antibody is a tool used to detect the LLGL1 protein, a key regulator of cell polarity and tissue organization. Encoded by the *LLGL1* gene, this scaffolding protein plays a critical role in establishing asymmetric cell division, maintaining epithelial cell polarity, and regulating cell adhesion. LLGL1 is part of conserved polarity complexes, such as the PAR (Partitioning Defective) network, and interacts with other polarity regulators like Scribble and Dlg. Dysregulation of LLGL1 has been linked to cancer progression, particularly in epithelial-derived tumors. Studies suggest that LLGL1 loss or mislocalization disrupts apical-basal polarity, promotes epithelial-mesenchymal transition (EMT), and enhances metastatic potential.

LLGL1 antibodies are widely used in research to investigate these mechanisms via techniques like Western blot, immunohistochemistry, and immunofluorescence. They help assess LLGL1 expression levels, subcellular localization, and interactions in normal versus diseased tissues. In cancer biology, LLGL1 antibody-based studies have revealed its tumor-suppressive role in breast, lung, and colorectal cancers, where reduced LLGL1 correlates with poor prognosis. Additionally, LLGL1 antibodies contribute to developmental biology research, as LLGL1 homologs in model organisms (e.g., Drosophila Lgl) are essential for embryonic patterning and neural development. These antibodies thus serve as vital reagents for unraveling the molecular basis of polarity-related diseases.