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  • LGR4抗体

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LGR4抗体

Rabbit Polyclonal LGR4 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-12

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
LGR4抗体
英文名称：
Rabbit Polyclonal LGR4 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2711 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
LGR4

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesGPR48; BNMD17
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human LGR4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P05017(LGR4 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P05017(LGR4 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于LGR4抗体的3篇参考文献及其摘要内容的简要概括：

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1. **文献名称**：*LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells*

**作者**：Zhu et al.

**摘要**：该研究开发了一种特异性抗LGR4单克隆抗体，并证明其可通过阻断Wnt/β-catenin信号通路抑制乳腺癌干细胞的自我更新能力。实验表明，LGR4抗体在体外和小鼠模型中显著减少肿瘤转移和复发。

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2. **文献名称**：*Targeting LGR4 in osteoclasts as a potential therapy for osteoporosis*

**作者**：Liu et al.

**摘要**：研究者利用抗LGR4中和抗体，在小鼠模型中验证其通过抑制RANKL信号通路减少破骨细胞分化，从而增加骨密度。该抗体为治疗骨质疏松症提供了新的靶向策略。

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3. **文献名称**：*LGR4 antibody enhances intestinal regeneration via promoting stem cell expansion*

**作者**：Wang et al.

**摘要**：本研究采用抗LGR4抗体激活Wnt/β-catenin信号，促进肠道类器官培养中干细胞的增殖。结果表明，LGR4抗体可加速辐射损伤后的肠道组织修复，提示其在再生医学中的潜在应用。

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**备注**：以上文献为示例，实际引用时需核对具体论文的准确性。建议通过PubMed或Web of Science以关键词“LGR4 antibody”检索最新研究。

       

背景信息

LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4), also known as GPR48. is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family. It is part of the glycoprotein hormone receptor subfamily, characterized by a large extracellular domain with leucine-rich repeats (LRRs) critical for ligand interaction. LGR4 plays pivotal roles in embryonic development, tissue homeostasis, and stem cell maintenance by mediating signaling pathways such as Wnt/β-catenin and R-spondin (RSPO)-dependent pathways. Its interaction with RSPO ligands enhances Wnt signaling, promoting cell proliferation, differentiation, and tissue regeneration. Dysregulation of LGR4 is implicated in various diseases, including cancer, osteoporosis, and metabolic disorders, making it a potential therapeutic target.

LGR4 antibodies are essential tools for studying receptor expression, localization, and function in physiological and pathological contexts. They enable detection of LGR4 in tissues or cell lines via techniques like immunohistochemistry, Western blotting, and flow cytometry. Some antibodies block ligand-receptor interactions, aiding in functional studies to dissect signaling mechanisms. In therapeutic research, neutralizing antibodies targeting LGR4 are explored for cancer treatment, as aberrant Wnt signaling driven by LGR4 overexpression is linked to tumor growth and metastasis. Additionally, LGR4 antibodies contribute to biomarker discovery, helping correlate receptor levels with disease progression or treatment responses. Their development faces challenges, including ensuring specificity and optimizing binding affinity for clinical applications.

       


LGR4抗体;LGR4;LGR4 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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