KIDINS220抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Raji cells, Hela cells, Primary antibody: P04999(KIDINS220 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

**Background of KIDINS220 Antibody**

KIDINS220 (Kinase D-Interacting Substrate of 220 kDa), also known as ARMS (Ankyrin Repeat-Rich Membrane Spanning protein), is a transmembrane scaffolding protein implicated in neuronal development, survival, and signaling. It interacts with neurotrophin receptors (e.g., TrkA, TrkB) and downstream effectors like Ras/MAPK and PLCγ pathways, regulating axonal growth, synaptic plasticity, and vesicle trafficking.

KIDINS220 antibodies are essential tools for studying its expression, localization, and functional roles. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect KIDINS220 in tissues or cultured cells. Research highlights its involvement in neurological disorders (e.g., Alzheimer’s disease, Huntington’s disease) and cancers (e.g., neuroblastoma, glioblastoma), where dysregulated KIDINS220 expression correlates with disease progression.

Antibodies targeting specific epitopes (e.g., N-terminal or C-terminal regions) help dissect its post-translational modifications and interactions. Recent studies also explore KIDINS220’s role in cardiovascular and immune systems, broadening its therapeutic relevance. Validated KIDINS220 antibodies are critical for advancing insights into its dual roles as a signaling hub and potential biomarker.