KCNMB1抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse heart and lung tissue, Primary antibody: P04994(KCNMB1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

The KCNMB1 antibody is a crucial tool for studying the β1 subunit of the large-conductance calcium-activated potassium (BK) channel, encoded by the *KCNMB1* gene. This subunit modulates BK channel activity by enhancing calcium sensitivity and regulating vascular smooth muscle tone, neuronal excitability, and secretory processes. KCNMB1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect protein expression, localization, and interactions in tissues such as smooth muscle, brain, and endocrine cells.

Research involving KCNMB1 antibodies has revealed its role in cardiovascular physiology, neuroprotection, and diseases like hypertension, epilepsy, and cancer. For example, β1 subunit dysfunction is linked to vascular abnormalities, while its overexpression in tumors may influence cancer progression. These antibodies also help explore genetic variants (e.g., Glu65Lys) associated with clinical phenotypes.

Available as monoclonal or polyclonal forms, KCNMB1 antibodies require validation via knockout controls or peptide blocking to ensure specificity. Their applications span drug development, biomarker discovery, and mechanistic studies of BK channel-related pathologies, making them essential for understanding cellular excitability and calcium signaling pathways.