KDM4C抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse heart tissue, Mouse brain tissue, Primary antibody: P04987(KDM4C Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

The KDM4C antibody is a crucial tool in studying the lysine demethylase 4C (KDM4C), also known as JMJD2C or GASC1. a member of the KDM4/JMJD2 histone demethylase family. KDM4C specifically catalyzes the removal of methyl groups from histone H3 lysine 9 trimethylation (H3K9me3) and H3 lysine 36 trimethylation (H3K36me3), modulating chromatin structure and gene expression. This enzyme plays pivotal roles in epigenetic regulation, influencing processes like transcriptional activation, heterochromatin maintenance, DNA repair, and cell cycle progression. Dysregulation of KDM4C is linked to cancers, developmental disorders, and metabolic diseases due to its oncogenic potential in promoting tumor growth, metastasis, and therapy resistance.

KDM4C antibodies are widely used in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). They aid in exploring KDM4C's role in disease mechanisms, drug discovery, and biomarker studies. Validated antibodies are essential for specificity, as the KDM4 family shares structural homology. Researchers often verify antibody performance using knockout cell lines or siRNA-mediated KDM4C depletion. Recent studies also focus on developing KDM4C inhibitors, making these antibodies vital for preclinical evaluation of targeted therapies aiming to restore epigenetic balance in malignancies.