KPNB1抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04969(KPNB1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04969(KPNB1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

**Background of KPNB1 Antibody**

KPNB1 (karyopherin β1), also known as importin β1. is a key nuclear transport receptor belonging to the importin β family. It plays a central role in mediating the transport of proteins from the cytoplasm into the nucleus through the nuclear pore complex (NPC). KPNB1 typically functions by binding to cargo proteins containing nuclear localization signals (NLS), either directly or via adaptor proteins like importin α, and facilitates their translocation across the NPC. This process is critical for regulating gene expression, cell cycle progression, and signal transduction.

Antibodies targeting KPNB1 are widely used in research to study nuclear-cytoplasmic transport mechanisms, protein localization, and interactions. They enable detection of KPNB1 expression levels, subcellular distribution (e.g., cytoplasmic vs. nuclear), and its association with disease pathologies. For instance, dysregulation of KPNB1 has been implicated in cancer (e.g., aberrant cell proliferation, drug resistance) and viral infections (e.g., hijacking nuclear transport by viral proteins). Additionally, KPNB1 antibodies are valuable tools in investigating neurodegenerative diseases linked to impaired nucleocytoplasmic trafficking.

These antibodies are commonly validated in applications such as Western blotting, immunofluorescence, immunoprecipitation, and immunohistochemistry, often with species cross-reactivity considerations. Their specificity and reliability make them essential for dissecting KPNB1's functional roles in both physiological and pathological contexts.