HMGCS1抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: P04931(HMGCS1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P04931(HMGCS1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04931(HMGCS1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) antibody is a crucial tool for studying the enzyme HMGCS1. a rate-limiting mitochondrial protein involved in ketogenesis and cholesterol biosynthesis. HMGCS1 catalyzes the condensation of acetoacetyl-CoA and acetyl-CoA to form HMG-CoA, a key intermediate in these metabolic pathways. Dysregulation of HMGCS1 has been linked to metabolic disorders, cancers (e.g., hepatocellular carcinoma), and neurodegenerative diseases, making it a research focus in metabolism and disease mechanisms.

HMGCS1 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, subcellular localization, and tissue distribution. Their specificity is critical for distinguishing HMGCS1 from its cytosolic isoform HMGCS2. which functions in ketone body production during fasting. Validated antibodies help elucidate HMGCS1's role in cellular energy homeostasis, lipid metabolism, and disease progression.

Commercial HMGCS1 antibodies are typically raised against peptide sequences unique to the human or murine protein, with applications in both basic research and clinical studies. Their utility extends to exploring therapeutic strategies targeting cholesterol synthesis pathways, particularly in cancer and cardiovascular diseases. Proper validation using knockout controls or siRNA knockdown is essential to ensure antibody reliability in experimental models.