ZNF395抗体

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P04922(ZNF395 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ZNF395 antibody is a tool used to detect the zinc finger protein 395 (ZNF395), a transcription factor encoded by the *ZNF395* gene located on human chromosome 19. ZNF395 belongs to the zinc finger protein family, characterized by conserved C2H2-type zinc finger domains that mediate DNA or RNA binding. This protein is implicated in cellular stress responses, including hypoxia and inflammation, and has been linked to cancer progression, neurodegenerative disorders, and metabolic regulation. Studies suggest ZNF395 interacts with hypoxia-inducible factor 1 (HIF-1) pathways and modulates gene expression under low-oxygen conditions. It is also associated with tumorigenesis in hepatocellular carcinoma, osteosarcoma, and glioblastoma, acting as either an oncogene or tumor suppressor depending on context.

ZNF395 antibodies are typically generated in rabbits or mice using recombinant protein immunogens. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study ZNF395's expression, localization, and interactions. Commercial antibodies often target specific epitopes within its N-terminal or zinc finger regions. Researchers utilize these antibodies to explore ZNF395's role in diseases, its regulation under stress, and potential therapeutic targets. However, variability in antibody specificity and batch consistency remains a challenge. Validated ZNF395 antibodies are critical for elucidating its dual roles in cancer and neurodegeneration, as well as its diagnostic or prognostic utility.