GAGE12I抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: K562 cells, Primary antibody: P04892(GAGE12I Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04892(GAGE12I Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04892(GAGE12I Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The GAGE12I antibody targets a member of the GAGE (G antigen) protein family, a group of cancer-testis antigens (CTAs) predominantly expressed in germline cells (e.g., testis, placenta) but aberrantly activated in various cancers. GAGE proteins, including GAGE12I, are characterized by a conserved PRAME-like structural domain and are implicated in tumorigenesis, immune evasion, and poor prognosis. Their restricted expression in normal tissues and reactivation in malignancies like melanoma, lung, and ovarian cancers make them attractive targets for immunotherapy and biomarker studies.

GAGE12I, encoded by the *GAGE12* gene cluster on chromosome X, shares homology with other GAGE family members but exhibits distinct expression patterns and potential functional roles. Studies suggest its involvement in regulating apoptosis, cell cycle progression, or epigenetic modifications, though exact mechanisms remain under investigation. Antibodies against GAGE12I are primarily utilized in research to detect its expression in tumor tissues, assess its diagnostic/prognostic relevance, and explore its role in cancer biology. Additionally, GAGE12I-specific antibodies support efforts to develop T cell-based therapies or vaccines targeting this antigen, leveraging its immunogenic properties. Despite therapeutic promise, challenges include addressing its low immunogenicity and ensuring tumor-specific targeting to minimize off-effects. Ongoing research aims to clarify its biological significance and translational potential in oncology.