FXR1抗体

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 and U251 celll ysates, Primary antibody: P04888(FXR1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04888(FXR1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04888(FXR1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

FXR1 (Fragile X Mental Retardation Syndrome-Related Protein 1) is an RNA-binding protein belonging to the FXR family, which includes FXR2 and FMR1 (FMRP). These proteins regulate translation and stability of target mRNAs, particularly in neuronal and muscular tissues. FXR1 plays critical roles in embryonic development, muscle function, and cellular stress responses. It forms complexes with other RNA-binding proteins, such as CYFIP2. to modulate mRNA transport and localized translation. Dysregulation of FXR1 is implicated in neurodevelopmental disorders, muscular dystrophies, and cancers, where it may influence tumor progression via mRNA metabolism pathways.

FXR1 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate FXR1's role in cellular processes. Researchers employ these antibodies to explore tissue-specific expression patterns, particularly in muscle and brain, and to identify post-translational modifications affecting FXR1 function. Some antibodies target specific isoforms generated through alternative splicing, enabling studies on isoform-specific activities. Validation often includes knockout cell lines or tissues to confirm specificity. Commercial FXR1 antibodies are typically raised against conserved regions (e.g., N-terminal or C-terminal epitopes) across multiple species, facilitating cross-species research. Recent studies using these antibodies have revealed FXR1's involvement in cancer cell invasion, neuromuscular junction maintenance, and viral RNA regulation, highlighting its diverse pathophysiological significance.