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  • FUT8抗体
  • FUT8抗体
  • FUT8抗体

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FUT8抗体

Rabbit Polyclonal FUT8 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-12

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
FUT8抗体
英文名称：
Rabbit Polyclonal FUT8 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2665 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
FUT8

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCDGF; CDGF1
WB Predicted band size67 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human FUT8
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: PC-3 cell lysate, Primary antibody: P04887(FUT8 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P04887(FUT8 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04887(FUT8 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是3-4条关于FUT8抗体的代表性参考文献摘要(基于公开信息整理，非真实文献，仅供示例参考)：

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1. **文献名称**: "FUT8-mediated core fucosylation regulates TGF-β receptor signaling and cancer metastasis"

**作者**: Zhao Y. et al.

**摘要**: 研究利用FUT8特异性抗体，通过免疫印迹和免疫组化分析，发现FUT8在多种癌症组织中高表达，并通过调控TGF-β受体核心岩藻糖基化促进上皮-间质转化(EMT)和肿瘤转移。

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2. **文献名称**: "FUT8 deficiency in mice results in defective immune regulation and autoimmune phenotypes"

**作者**: Wang X. et al.

**摘要**: 通过基因敲除小鼠模型及FUT8抗体检测，发现FUT8缺失导致调节性T细胞(Treg)功能异常，引发自身免疫反应，提示FUT8在免疫稳态中的关键作用。

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3. **文献名称**: "Antibody-based detection of FUT8 activity as a biomarker for rheumatoid arthritis progression"

**作者**: Li H. et al.

**摘要**: 开发了一种基于FUT8抗体的ELISA检测方法，发现类风湿性关节炎患者血清中FUT8活性升高，与疾病严重程度呈正相关，为临床诊断提供潜在标志物。

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4. **文献名称**: "Structural analysis of FUT8-glycosylated antibodies using monoclonal anti-FUT8 probes"

**作者**: Agrawal P. et al.

**摘要**: 利用高特异性FUT8抗体探针，结合质谱技术解析了抗体Fc段核心岩藻糖基化结构，证实其对抗体依赖细胞毒(ADCC)效应的调控机制。

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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“FUT8 antibody”、“FUT8 fucosyltransferase”或结合具体研究领域(如癌症、糖基化)。

       

背景信息

**Background of FUT8 Antibody**

FUT8 (α-1.6-fucosyltransferase) is a key enzyme that catalyzes the transfer of fucose to the core N-glycans of glycoproteins via an α-1.6 linkage, a process critical for modulating protein functions such as cell signaling, immune regulation, and protein stability. Dysregulation of FUT8 activity is linked to various diseases, including cancer, autoimmune disorders, and inflammatory conditions.

FUT8 antibodies are essential tools for studying the expression, localization, and functional roles of FUT8 in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect FUT8 in tissues or cell lines. Monoclonal FUT8 antibodies offer high specificity, while polyclonal versions may detect broader epitopes.

Research using FUT8 antibodies has revealed its involvement in cancer progression, where elevated FUT8 expression correlates with tumor metastasis and poor prognosis, potentially due to its role in modifying growth factor receptors (e.g., EGFR, TGF-βR). Conversely, FUT8 deficiency is associated with autoimmune disorders like rheumatoid arthritis.

The development of FUT8 inhibitors or antibody-based therapies is an emerging area, highlighting FUT8 as a biomarker and therapeutic target. Validated FUT8 antibodies are crucial for advancing glycobiology research and understanding disease mechanisms linked to aberrant protein fucosylation.

       
FUT8抗体;FUT8;FUT8 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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