EPPIN抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: NIH/3T3 cells, human testis tissue, mouse fat tissue, Primary antibody: P04852(EPPIN Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04852(EPPIN Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04852(EPPIN Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

EPPIN (Epididymal Protease Inhibitor) is a small, cysteine-rich protein predominantly expressed in the male reproductive tract, particularly in the epididymis and on the surface of spermatozoa. It plays a critical role in regulating sperm maturation, motility, and fertilization by interacting with semenogelin, a seminal vesicle protein, to modulate protease activity during ejaculation. EPPIN’s involvement in sperm function has made it a target for research in male contraception and infertility.

Antibodies against EPPIN have been developed to study its biological mechanisms and potential contraceptive applications. Studies suggest that anti-EPPIN antibodies can inhibit sperm motility and block sperm-egg interaction by interfering with EPPIN’s functional domains. This has spurred interest in EPPIN-based immunocontraceptive strategies, aiming to induce an immune response that neutralizes sperm function without affecting hormonal balance.

However, challenges remain, including optimizing antibody specificity to avoid cross-reactivity with other proteins and ensuring reversible effects. Research also explores EPPIN’s role in male infertility, as altered expression or mutations may correlate with impaired sperm quality. Overall, EPPIN antibodies serve as valuable tools for both understanding reproductive biology and developing novel therapeutic or contraceptive interventions.