DUSP2抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse thymus tissue, Mouse liver tissue lysates, Primary antibody: P04839(DUSP2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

The DUSP2 antibody is a research tool designed to detect and study dual-specificity phosphatase 2 (DUSP2), a member of the MAP kinase phosphatase (MKP) family. DUSP2. also known as PAC-1. regulates mitogen-activated protein kinase (MAPK) signaling by dephosphorylating and inactivating ERK, JNK, and p38 kinases. It plays a critical role in immune responses, cell proliferation, and apoptosis. DUSP2 is notably expressed in immune cells, including macrophages, where it modulates inflammatory signaling pathways.

Antibodies targeting DUSP2 are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to analyze protein expression, localization, and function. Researchers employ these antibodies to investigate DUSP2's involvement in diseases such as cancer, autoimmune disorders, and chronic inflammation. For instance, studies suggest DUSP2 downregulation in certain tumors may enhance MAPK-driven oncogenic signaling, while its overexpression in inflammatory conditions could suppress pro-inflammatory cytokine production.

Validating DUSP2 antibody specificity is crucial, often achieved through knockout controls or peptide blocking experiments. Its applications extend to understanding cellular responses to stress, growth factors, and therapeutic agents targeting MAPK pathways. As dysregulated DUSP2 expression correlates with pathological states, this antibody remains vital for elucidating molecular mechanisms in immunology, oncology, and drug development research.