DTX1抗体

The DTX1 antibody is a crucial tool in studying the Deltex1 (DTX1) protein, a member of the Deltex family of E3 ubiquitin ligases involved in the Notch signaling pathway. DTX1 plays a regulatory role in cellular processes such as differentiation, proliferation, and apoptosis by mediating protein ubiquitination and degradation. Initially identified as a Notch pathway modulator, DTX1 interacts with Notch receptors to influence downstream transcriptional activity, though its role can vary across cell types and contexts. Research has linked DTX1 to immune regulation, neurodevelopment, and cancer, where it may act as either an oncogene or tumor suppressor depending on the cellular environment. The DTX1 antibody enables detection and quantification of DTX1 expression in tissues or cell lines, aiding investigations into its functional mechanisms and disease associations. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent studies highlight DTX1's involvement in T-cell activation, B-cell malignancies, and drug resistance, underscoring its therapeutic and diagnostic potential. However, antibody specificity and validation remain critical considerations due to protein isoforms and cross-reactivity risks.