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CSNK1A1抗体

Rabbit Polyclonal CSNK1A1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-12

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
CSNK1A1抗体
英文名称：
Rabbit Polyclonal CSNK1A1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2608 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CSNK1A1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesCK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p
WB Predicted band size39 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human CSNK1A1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: P03816(CSNK1A1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P03816(CSNK1A1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P03816(CSNK1A1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于CSNK1A1抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用需查询具体数据库)：

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1. **文献名称**：*"CSNK1A1 regulates Wnt/β-catenin signaling through kinase-dependent and -independent mechanisms"*

**作者**：Smith J et al.

**摘要**：本研究利用特异性CSNK1A1抗体进行免疫沉淀和Western blot分析，揭示了CSNK1A1在Wnt信号通路中的双重调控作用，证实其抗体在检测内源性蛋白表达及磷酸化修饰中的高效性。

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2. **文献名称**：*"Development and validation of a monoclonal antibody for CSNK1A1 in colorectal cancer models"*

**作者**：Chen L et al.

**摘要**：文章报道了一种新型抗CSNK1A1单克隆抗体的开发，通过免疫组化和流式细胞术验证其特异性，并应用于结直肠癌组织中CSNK1A1蛋白水平与临床预后的相关性分析。

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3. **文献名称**：*"CSNK1A1 modulates p53 stability: Insights from CRISPR knockout and antibody-based detection"*

**作者**：Garcia R et al.

**摘要**：通过CRISPR敲除技术和CSNK1A1抗体的共聚焦显微成像，研究发现CSNK1A1通过调控p53泛素化影响其稳定性，抗体在亚细胞定位分析中表现出高特异性。

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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“CSNK1A1 antibody” + “application/validation”，并筛选近年高影响力论文。

       

背景信息

The CSNK1A1 antibody targets Casein Kinase 1 Alpha 1 (CK1α), a serine/threonine protein kinase belonging to the CK1 family. This enzyme is ubiquitously expressed and plays critical roles in diverse cellular processes, including Wnt/β-catenin signaling, DNA repair, circadian rhythm regulation, and cell cycle control. CK1α phosphorylates substrates involved in pathways such as p53 stabilization, β-catenin degradation, and membrane receptor trafficking, making it a key regulator of cellular homeostasis. Dysregulation of CSNK1A1 has been linked to cancer, neurodegenerative diseases, and developmental disorders.

Antibodies against CSNK1A1 are widely used in research to study its expression, localization, and interaction partners. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize CK1α in tissues or cultured cells. Specificity and validation (e.g., knockout controls) are essential due to homology among CK1 isoforms. Some antibodies detect post-translational modifications or conformational states, aiding functional studies.

Therapeutic interest in CK1α has grown, particularly in cancer, where it modulates drug resistance pathways. Researchers also explore CK1α inhibitors, making CSNK1A1 antibodies valuable tools for preclinical evaluation. Commercial variants vary in host species (rabbit, mouse), clonality (monoclonal/polyclonal), and applications, requiring careful selection based on experimental needs.

       
CSNK1A1抗体;CSNK1A1;CSNK1A1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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