Ccl6抗体

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P03799(Ccl6 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of CCL6 Antibody**

CCL6 (C-C motif chemokine ligand 6), also known as C10 or MRP-1 (myeloid-related protein 1), is a small secretory protein belonging to the CC chemokine family. It functions as a chemoattractant for immune cells, including monocytes, macrophages, and neutrophils, by interacting with receptors such as CCR1. CCR2. and CCR3. CCL6 is primarily studied in murine models, where it plays roles in inflammatory responses, tissue remodeling, and immune regulation. It is implicated in diseases like cancer, fibrosis, and autoimmune disorders, where it modulates immune cell infiltration and microenvironment dynamics.

CCL6 antibodies are tools used to detect and quantify CCL6 protein expression in experimental settings. They enable researchers to study CCL6's spatial and temporal distribution in tissues, its secretion patterns, and its functional interactions in vitro and in vivo. These antibodies are critical for techniques such as Western blotting, immunohistochemistry, flow cytometry, and ELISA. Neutralizing CCL6 antibodies can also block its activity, helping to dissect its role in disease pathways or therapeutic contexts.

Notably, while CCL6 is well-characterized in mice, its human ortholog, CCL23. shares structural and functional similarities but differs in gene regulation and disease associations. This distinction highlights the importance of species-specific antibody validation in translational research. Overall, CCL6 antibodies serve as essential reagents for exploring chemokine-mediated immunity and inflammation.