POU2AF1抗体

The POU2AF1 antibody is a research tool targeting the POU2AF1 protein, also known as OCA-B or Bob1. which plays a critical role in B-cell development and immune function. POU2AF1 is a transcriptional coactivator that binds to POU2F2 (Oct-2), facilitating its interaction with immunoglobulin gene promoters to regulate B-cell-specific gene expression. This protein is essential for germinal center formation, antibody production, and mature B-cell differentiation. Antibodies against POU2AF1 are widely used in immunology and cancer research to study its expression patterns, particularly in B-cell malignancies such as diffuse large B-cell lymphoma (DLBCL) and Hodgkin's lymphoma. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry, aiding in the characterization of normal and dysregulated B-cell pathways. In clinical contexts, POU2AF1 expression levels may serve as a diagnostic or prognostic marker, with reduced expression linked to certain lymphoma subtypes. Researchers also utilize these antibodies to explore POU2AF1's role in autoimmune diseases and its potential as a therapeutic target. Most commercially available POU2AF1 antibodies are raised in rabbits or mice and validated for specificity across human and murine samples.